Cooking Up a Breakthrough: Penn Engineers Refine Lipid Nanoparticles for Better mRNA Therapies News / November 22, 2024 Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 vaccines and other innovative therapies. The method, described in Nature Biomedical Engineering, mirrors the iterative process of developing a... Read More
Penn’s Siloxane-Enhanced Nanoparticles Chart a New Path in Precision mRNA Medicine News / October 1, 2024 Penn Engineers have discovered a novel means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, presaging a new era in personalized medicine and gene therapy. While past research — including at Penn Engineering — has screened “libraries” of LNPs to find... Read More
